3,930 research outputs found
Consensual Qualitative Research: An Update
The authors reviewed the application of consensual qualitative research (CQR) in 27 studies published since the method’s introduction to the field in 1997 by C. E. Hill, B. J. Thompson, and E. N. Williams (1997). After first describing the core components and the philosophical underpinnings of CQR, the authors examined how it has been applied in terms of the consensus process, biases, research teams, data collection, data analysis, and writing up the results and discussion sections of articles. On the basis of problems that have arisen in each of these areas, the authors made recommendations for modifications of the method. The authors concluded that CQR is a viable qualitative method and suggest several ideas for research on the method itself
Mass production of volume phase holographic gratings for the VIRUS spectrograph array
The Visible Integral-field Replicable Unit Spectrograph (VIRUS) is a baseline
array of 150 copies of a simple, fiber-fed integral field spectrograph that
will be deployed on the Hobby-Eberly Telescope (HET). VIRUS is the first
optical astronomical instrument to be replicated on an industrial scale, and
represents a relatively inexpensive solution for carrying out large-area
spectroscopic surveys, such as the HET Dark Energy Experiment (HETDEX). Each
spectrograph contains a volume phase holographic (VPH) grating with a 138 mm
diameter clear aperture as its dispersing element. The instrument utilizes the
grating in first-order for 350-550 nm. Including witness samples, a suite of
170 VPH gratings has been mass produced for VIRUS. Here, we present the design
of the VIRUS VPH gratings and a discussion of their mass production. We
additionally present the design and functionality of a custom apparatus that
has been used to rapidly test the first-order diffraction efficiency of the
gratings for various discrete wavelengths within the VIRUS spectral range. This
device has been used to perform both in-situ tests to monitor the effects of
adjustments to the production prescription as well as to carry out the final
acceptance tests of the gratings' diffraction efficiency. Finally, we present
the as-built performance results for the entire suite of VPH gratings.Comment: 16 pages, 11 figures, 2 tables. To be published in Proc. SPIE, 2014,
"Advances in Optical and Mechanical Technologies for Telescopes and
Instrumentation", 9151-53. The work presented in this article follows from
arXiv:1207:448
Ontology of the apelinergic system in mouse pancreas during pregnancy and relationship with β-cell mass
The apelin receptor (Aplnr) and its ligands, Apelin and Apela, contribute to metabolic control. The insulin resistance associated with pregnancy is accommodated by an expansion of pancreatic β-cell mass (BCM) and increased insulin secretion, involving the proliferation of insulin-expressing, glucose transporter 2-low (Ins+Glut2LO) progenitor cells. We examined changes in the apelinergic system during normal mouse pregnancy and in pregnancies complicated by glucose intolerance with reduced BCM. Expression of Aplnr, Apelin and Apela was quantified in Ins+Glut2LO cells isolated from mouse pancreata and found to be significantly higher than in mature β-cells by DNA microarray and qPCR. Apelin was localized to most β-cells by immunohistochemistry although Aplnr was predominantly associated with Ins+Glut2LO cells. Aplnr-staining cells increased three- to four-fold during pregnancy being maximal at gestational days (GD) 9–12 but were significantly reduced in glucose intolerant mice. Apelin-13 increased β-cell proliferation in isolated mouse islets and INS1E cells, but not glucose-stimulated insulin secretion. Glucose intolerant pregnant mice had significantly elevated serum Apelin levels at GD 9 associated with an increased presence of placental IL-6. Placental expression of the apelinergic axis remained unaltered, however. Results show that the apelinergic system is highly expressed in pancreatic β-cell progenitors and may contribute to β-cell proliferation in pregnancy
The 1.88 Ga Kotalahti and Vammala nickel belts, Finland: geochemistry of the mafic and ultramafic metavolcanic rocks
The mafic and ultramafic volcanic rocks within the Svecofennian (1.88 Ga) Kotalahti and Vammala Nickel Belts, Finland, are spatially associated and coeval with a suite of mineralized mafic–ultramafic intrusions. They have been divided into five suites based on major element geochemistry and spatial distribution: the Rantasalmi high- and low-Mg suites, the Vammala high-Mg suite, and the Rantasalmi, Kestilä and Pielavesi low-Mg suites. The Rantasalmi and Vammala high-Mg suites are very similar and probably comagmatic, and the Kestilä and Rantasalmi low-Mg suites are derived from them by a combination of fractionation and crustal assimilation. The Pielavesi suite is interpreted as an unrelated suite of island-arc affinity.On the basis of their trace element contents, the Kotalahti Belt intrusions are comagmatic with part of the analyzed volcanic rocks. In the Vammala Belt it is likely that the parent magmas to the intrusions and picrite magmas have a common mantle source but have evolved along distinct paths, and the picrites probably do not represent parent magmas tapped directly from the intrusions. Platinum-group element data show localised evidence for depletionby sulfide extraction. Vammala picrites are predominantly S-undersaturated, with the exception of lavas in the Stormi area. In the Kotalahti Belt the volcanic rocks are predominantlyS-undersaturated, while the volcanic rocks in the more northern part of the Belt are predominantly S-saturated. These spatial differences imply that the PGE contents of the metavolcanic rocks can be used as regional area selection criteria for intrusive nickel-copper-(PGE) deposits within the Finnish Svecofennian
Influenza vaccination coverage among an urban pediatric asthma population: Implications for population health
Introduction Asthma is the most common chronic disease in children. Children with asthma are at high risk for complications from influenza; however annual influenza vaccination rates for this population are suboptimal. The overall aim of this study was to describe the characteristics of a high-risk population of children with asthma presenting to an urban pediatric emergency department according to influenza vaccination status. Methods The study was a retrospective chart review of 4355 patients aged 2 to 18 years evaluated in a Michigan pediatric emergency department (PED) between November 1, 2017 and April 30, 2018 with an ICD-10-CM code for asthma (J45.x). Eligible patient PED records were matched with influenza vaccination records for the 2017–2018 influenza season from the Michigan Care Improvement Registry. Geospatial analysis was employed to examine the distribution of influenza vaccination status. Results 1049 patients (30.9%) with asthma seen in the PED had received an influenza vaccine. Influenza vaccination coverage varied by Census Tract, ranging from 10% to \u3e 99%. Most vaccines were administered in a primary care setting (84.3%) and were covered by public insurance (76.8%). The influenza vaccination rate was lowest for children aged 5–11 years (30.0%) and vaccination status was associated with race (p\u3c0.001) and insurance type (p\u3c0.001). Conclusions Identification of neighborhood Census Tract and demographic groups with suboptimal influenza vaccination could guide development of targeted public health interventions to improve vaccination rates in high-risk patients. Given the morbidity and mortality associated with pediatric asthma, a data-driven approach may improve outcomes and reduce healthcare-associated costs for this pediatric population
The Influence of Motion and Stress on Optical Fibers
We report on extensive testing carried out on the optical fibers for the
VIRUS instrument. The primary result of this work explores how 10+ years of
simulated wear on a VIRUS fiber bundle affects both transmission and focal
ratio degradation (FRD) of the optical fibers. During the accelerated lifetime
tests we continuously monitored the fibers for signs of FRD. We find that
transient FRD events were common during the portions of the tests when motion
was at telescope slew rates, but dropped to negligible levels during rates of
motion typical for science observation. Tests of fiber transmission and FRD
conducted both before and after the lifetime tests reveal that while
transmission values do not change over the 10+ years of simulated wear, a clear
increase in FRD is seen in all 18 fibers tested. This increase in FRD is likely
due to microfractures that develop over time from repeated flexure of the fiber
bundle, and stands in contrast to the transient FRD events that stem from
localized stress and subsequent modal diffusion of light within the fibers.
There was no measurable wavelength dependence on the increase in FRD over 350
nm to 600 nm. We also report on bend radius tests conducted on individual
fibers and find the 266 microns VIRUS fibers to be immune to bending-induced
FRD at bend radii of R > 10cm. Below this bend radius FRD increases slightly
with decreasing radius. Lastly, we give details of a degradation seen in the
fiber bundle currently deployed on the Mitchell Spectrograph (formally VIRUS-P)
at McDonald Observatory. The degradation is shown to be caused by a localized
shear in a select number of optical fibers that leads to an explosive form of
FRD. In a few fibers, the overall transmission loss through the instrument can
exceed 80%.Comment: 19 pages, 22 figure
A Summary of the Lateral Cutoff Analysis and Results from Nasa's Farfield Investigation of No-Boom Thresholds
In support of the ongoing effort by the National Aeronautics and Space Administration (NASA) to bring supersonic commercial travel to the public, NASA, in partnership with other industry organizations, conducted a flight research experiment to analyze acoustic propagation at the lateral edge of the sonic boom carpet. The name of the effort was the Farfield Investigation of No-boom Thresholds (FaINT). The research from FaINT determined an appropriate metric for sonic boom waveforms in the transition and shadow zones called Perceived Sound Exposure Level, established a value of 65 dB as a limit for the acoustic lateral extent of a sonic boom's noise region, analyzed change in sonic boom levels near lateral cutoff, and compared between real sonic boom measurements and numerical predictions
Altered pancreas remodeling following glucose intolerance in pregnancy in mice
Gestational diabetes mellitus increases the risk of dysglycemia postpartum, in part, due to pancreatic β-cell dysfunction. However, no histological evidence exists comparing endocrine pancreas after healthy and glucose-intolerant pregnancies. This study sought to address this knowledge gap, in addition to exploring the contribution of an inflammatory environment to changes in endocrine pancreas after parturition. We used a previously established mouse model of gestational glucose intolerance induced by dietary low protein insult from conception until weaning. Pancreas and adipose samples were collected at 7, 30 and 90 days postpartum for histomorphometric and cytokine analyses, respectively. Glucose tolerance tests were performed prior to euthanasia and blood was collected via cardiac puncture. Pregnant female mice born to dams fed a low protein diet previously shown to develop glucose intolerance at late gestation relative to controls continued to be glucose intolerant until 1 month postpartum. However, glucose tolerance normalized by 3 months postpartum. Glucose intolerance at 7 days postpartum was associated with lower beta- and alpha-cell fractional areas and higher adipose levels of pro-inflammatory cytokine, interleukin-6. By 3 months postpartum, a compensatory increase in the number of small islets and a higher insulin to glucagon ratio likely enabled euglycemia to be attained in the previously glucose-intolerant mice. The results show that impairments in endocrine pancreas compensation in hyperglycemic pregnancy persist after parturition and contribute to prolonged glucose intolerance. These impairments may increase the susceptibility to development of future type 2 diabetes
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